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Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts
The effect of cis-diaminedichloroplatinum(II) (cisplatin) DNA damage on the repair of double-strand breaks by non-homologous end-joining (NHEJ) was determined using cell-free extracts. NHEJ was dramatically decreased when plasmid DNA was damaged to contain multiple types of DNA adducts, along the mo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1088968/ https://ncbi.nlm.nih.gov/pubmed/15872216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki528 |
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