N Terminus of Sos1 Ras Exchange Factor: Critical Roles for the Dbl and Pleckstrin Homology Domains

We have studied the functional importance of the N terminus of mouse Sos1 (mSos1), a ubiquitously expressed Ras-specific guanine nucleotide exchange factor whose C-terminal sequences bind Grb-2. Consistent with previous reports, addition of a myristoylation signal to mSos1 (MyrSos1) rendered it tran...

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Auteurs principaux: Qian, Xiaolan, Vass, William C., Papageorge, Alex G., Anborgh, Pieter H., Lowy, Douglas R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 1998
Sujets:
Cell Growth and Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC108788/
https://ncbi.nlm.nih.gov/pubmed/9447973
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