Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

The von Hippel-Lindau tumor suppressor protein (pVHL) binds to elongins B and C and posttranscriptionally regulates the accumulation of hypoxia-inducible mRNAs under normoxic (21% O(2)) conditions. Here we report that pVHL binds, via elongin C, to the human homolog of the Caenorhabditis elegans Cul2...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Lonergan, Kim M., Iliopoulos, Othon, Ohh, Michael, Kamura, Takumi, Conaway, Ronald C., Conaway, Joan Weliky, Kaelin, William G.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1998
Schlagworte:	Transcriptional Regulation
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108784/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9447969/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.2.732
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