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Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

The von Hippel-Lindau tumor suppressor protein (pVHL) binds to elongins B and C and posttranscriptionally regulates the accumulation of hypoxia-inducible mRNAs under normoxic (21% O(2)) conditions. Here we report that pVHL binds, via elongin C, to the human homolog of the Caenorhabditis elegans Cul2...

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Udgivet i:Mol Cell Biol
Principais autores: Lonergan, Kim M., Iliopoulos, Othon, Ohh, Michael, Kamura, Takumi, Conaway, Ronald C., Conaway, Joan Weliky, Kaelin, William G.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1998
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108784/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9447969/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.2.732
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