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Regulation of the Small GTPase Rap1 and Extracellular Signal-Regulated Kinases by the Costimulatory Molecule CTLA-4

The mitogen-activated protein kinase extracellular signal-regulated kinase (ERK) is activated following engagement of the T-cell receptor and is required for interleukin 2 (IL-2) production and T-cell proliferation. This activation is enhanced by stimulation of the coreceptor CD28 and inhibited by t...

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Detalhes bibliográficos
Main Authors: Dillon, Tara J., Carey, Kendall D., Wetzel, Scott A., Parker, David C., Stork, Philip J. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087740/
https://ncbi.nlm.nih.gov/pubmed/15870282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.4117-4128.2005
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