The Human β-Globin Locus Control Region Can Silence as Well as Activate Gene Expression

Using recombinase-mediated cassette exchange to test multiple transgenes at the same site of integration, we demonstrate a novel chromatin context-dependent silencer activity of the β-globin locus control region (LCR). This silencer activity requires DNase I hypersensitive sites HS2 and HS3 but not...

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Autores principales: Feng, Yong-Qing, Warin, Renaud, Li, Taihao, Olivier, Emmanuel, Besse, Arnaud, Lobell, Amanda, Fu, Haiqing, Lin, Chii Mei, Aladjem, Mirit I., Bouhassira, Eric E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087713/
https://ncbi.nlm.nih.gov/pubmed/15870261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.3864-3874.2005
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