DNA Methylation Supports Intrinsic Epigenetic Memory in Mammalian Cells

We have investigated the role of DNA methylation in the initiation and maintenance of silenced chromatin in somatic mammalian cells. We found that a mutated transgene, in which all the CpG dinucleotides have been eliminated, underwent transcriptional silencing to the same extent as the unmodified tr...

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Detalhes bibliográficos
Main Authors: Feng, Yong-Qing, Desprat, Romain, Fu, Haiqing, Olivier, Emmanuel, Lin, Chii Mei, Lobell, Amanda, Gowda, Shilpa N, Aladjem, Mirit I, Bouhassira, Eric E
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449906/
https://ncbi.nlm.nih.gov/pubmed/16683039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020065
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