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DNA Methylation Supports Intrinsic Epigenetic Memory in Mammalian Cells
We have investigated the role of DNA methylation in the initiation and maintenance of silenced chromatin in somatic mammalian cells. We found that a mutated transgene, in which all the CpG dinucleotides have been eliminated, underwent transcriptional silencing to the same extent as the unmodified tr...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science
2006
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1449906/ https://ncbi.nlm.nih.gov/pubmed/16683039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020065 |
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