A Novel MATE Family Efflux Pump Contributes to the Reduced Susceptibility of Laboratory-Derived Staphylococcus aureus Mutants to Tigecycline

Tigecycline, an expanded-broad-spectrum glycylcycline antibiotic is not affected by the classical tetracycline resistance determinants found in Staphylococcus aureus. The in vitro selection of mutants with reduced susceptibility to tigecycline was evaluated for two methicillin-resistant S. aureus st...

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Bibliografiske detaljer
Main Authors: McAleese, Fionnuala, Petersen, Peter, Ruzin, Alexey, Dunman, Paul M., Murphy, Ellen, Projan, Steven J., Bradford, Patricia A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087644/
https://ncbi.nlm.nih.gov/pubmed/15855508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1865-1871.2005
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