A Novel MATE Family Efflux Pump Contributes to the Reduced Susceptibility of Laboratory-Derived Staphylococcus aureus Mutants to Tigecycline

Tigecycline, an expanded-broad-spectrum glycylcycline antibiotic is not affected by the classical tetracycline resistance determinants found in Staphylococcus aureus. The in vitro selection of mutants with reduced susceptibility to tigecycline was evaluated for two methicillin-resistant S. aureus st...

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Autores principales: McAleese, Fionnuala, Petersen, Peter, Ruzin, Alexey, Dunman, Paul M., Murphy, Ellen, Projan, Steven J., Bradford, Patricia A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087644/
https://ncbi.nlm.nih.gov/pubmed/15855508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1865-1871.2005
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