A Novel MATE Family Efflux Pump Contributes to the Reduced Susceptibility of Laboratory-Derived Staphylococcus aureus Mutants to Tigecycline

Tigecycline, an expanded-broad-spectrum glycylcycline antibiotic is not affected by the classical tetracycline resistance determinants found in Staphylococcus aureus. The in vitro selection of mutants with reduced susceptibility to tigecycline was evaluated for two methicillin-resistant S. aureus st...

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Detalhes bibliográficos
Main Authors: McAleese, Fionnuala, Petersen, Peter, Ruzin, Alexey, Dunman, Paul M., Murphy, Ellen, Projan, Steven J., Bradford, Patricia A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087644/
https://ncbi.nlm.nih.gov/pubmed/15855508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1865-1871.2005
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