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Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
Partial restoration of insulin receptor Insr expression in brain, liver, and pancreatic β cells is sufficient for rescuing Insr knockout mice from neonatal death, preventing diabetes ketoacidosis, and normalizing life span and reproductive function. However, the transgenically rescued mice (referred...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1087162/ https://ncbi.nlm.nih.gov/pubmed/15864351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523096 |
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