Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice

Insulin exerts its potent effects on hepatic glucose fluxes via direct and indirect mechanisms. Whereas a liver-specific insulin receptor (IR) knockout (LIRKO) mouse exhibits glucose intolerance as well as insulin resistance, it is unclear whether a more acute decrease in the expression of hepatic I...

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Bibliographic Details
Main Authors: Buettner, Christoph, Patel, Rima, Muse, Evan D., Bhanot, Sanjay, Monia, Brett P., McKay, Rob, Obici, Silvana, Rossetti, Luciano
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087163/
https://ncbi.nlm.nih.gov/pubmed/15864350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523109
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