Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Mice with targeted deletion of the gene for interleukin-10 (IL-10) spontaneously develop enterocolitis when maintained in conventional conditions but develop only colitis when kept in specific-pathogen-free (SPF) environments. This study tested the hypothesis that enteric bacteria are necessary for...

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Main Authors: Sellon, Rance K., Tonkonogy, Susan, Schultz, Michael, Dieleman, Levinus A., Grenther, Wetonia, Balish, Ed, Rennick, Donna M., Sartor, R. Balfour
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1998
Assuntos:
Molecular and Cellular Pathogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC108652/
https://ncbi.nlm.nih.gov/pubmed/9784526
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