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Helicobacter hepaticus-Induced Colitis in Interleukin-10-Deficient Mice: Cytokine Requirements for the Induction and Maintenance of Intestinal Inflammation

We have previously shown that specific-pathogen-free interleukin-10 (IL-10)-deficient (IL-10 KO) mice reconstituted with Helicobacter hepaticus develop severe colitis associated with a Th1-type cytokine response. In the present study, we formally demonstrate that IL-12 is crucial for disease inducti...

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Dettagli Bibliografici
Autori principali: Kullberg, Marika C., Rothfuchs, Antonio Gigliotti, Jankovic, Dragana, Caspar, Patricia, Wynn, Thomas A., Gorelick, Peter L., Cheever, Allen W., Sher, Alan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC98456/
https://ncbi.nlm.nih.gov/pubmed/11401959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.7.4232-4241.2001
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