Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Mice with targeted deletion of the gene for interleukin-10 (IL-10) spontaneously develop enterocolitis when maintained in conventional conditions but develop only colitis when kept in specific-pathogen-free (SPF) environments. This study tested the hypothesis that enteric bacteria are necessary for...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Sellon, Rance K., Tonkonogy, Susan, Schultz, Michael, Dieleman, Levinus A., Grenther, Wetonia, Balish, Ed, Rennick, Donna M., Sartor, R. Balfour
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Molecular and Cellular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108652/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9784526/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.11.5224-5231.1998
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