Paromomycin and Geneticin Inhibit Intracellular Cryptosporidium parvum without Trafficking through the Host Cell Cytoplasm: Implications for Drug Delivery

Cryptosporidium parvum, which causes intractable diarrhea and lethal wasting in people with AIDS, occupies an unusual intracellular but extracytoplasmic niche. No reliable therapy for cryptosporidiosis exists, though the aminoglycoside paromomycin is somewhat effective. We report that paromomycin an...

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Bibliografische Detailangaben

Veröffentlicht in:	Infect Immun
Hauptverfasser:	Griffiths, Jeffrey K., Balakrishnan, Ramaswamy, Widmer, Giovanni, Tzipori, Saul
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Molecular and Cellular Pathogenesis
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9673275/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.8.3874-3883.1998
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