Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Human checkpoint kinase 1 (Chk1) is an essential kinase required to preserve genome stability. Here, we show that Chk1 inhibition by two distinct drugs, UCN-01 and CEP-3891, or by Chk1 small interfering RNA (siRNA) leads to phosphorylation of ATR targets. Chk1-inhibition triggered rapid, pan-nuclear...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Syljuåsen, Randi G., Sørensen, Claus Storgaard, Hansen, Lasse Tengbjerg, Fugger, Kasper, Lundin, Cecilia, Johansson, Fredrik, Helleday, Thomas, Sehested, Maxwell, Lukas, Jiri, Bartek, Jiri
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
主題:
Gene Expression
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084285/
https://ncbi.nlm.nih.gov/pubmed/15831461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3553-3562.2005
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍