Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Human checkpoint kinase 1 (Chk1) is an essential kinase required to preserve genome stability. Here, we show that Chk1 inhibition by two distinct drugs, UCN-01 and CEP-3891, or by Chk1 small interfering RNA (siRNA) leads to phosphorylation of ATR targets. Chk1-inhibition triggered rapid, pan-nuclear...

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Detalhes bibliográficos
Main Authors: Syljuåsen, Randi G., Sørensen, Claus Storgaard, Hansen, Lasse Tengbjerg, Fugger, Kasper, Lundin, Cecilia, Johansson, Fredrik, Helleday, Thomas, Sehested, Maxwell, Lukas, Jiri, Bartek, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084285/
https://ncbi.nlm.nih.gov/pubmed/15831461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3553-3562.2005
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