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Hypoxia-inducible factor-1α (HIF-1α) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm
Eukaryotic cells sense oxygen and adapt to hypoxia by regulating a number of genes. Hypoxia-inducible factor 1 (HIF-1) is the ‘master’ in this pleiotypic response. HIF-1 comprises two members of the basic helix–loop–helix transcription factor family, HIF-1α and HIF-1β. The HIF-1α protein is subject...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083944/ https://ncbi.nlm.nih.gov/pubmed/11454738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve130 |
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