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Mapping of a human centromere onto the DNA by topoisomerase II cleavage
We have mapped the positions of topoisomerase II binding sites at the centromere of the human Y chromosome using etoposide-mediated DNA cleavage. A single region of cleavage is seen at normal centromeres, spanning ∼50 kb within the centromeric alphoid array, but this pattern is abolished at two inac...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2000
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083782/ https://ncbi.nlm.nih.gov/pubmed/11263492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd110 |
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