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Curbing the nuclear activities of β-catenin: Control over Wnt target gene expression

Wnt molecules control numerous developmental processes by altering specific gene expression patterns, and deregulation of Wnt signaling can lead to cancer. Many Wnt factors employ β-catenin as a nuclear effector. Upon Wnt stimulation, β-catenin heterodimerizes with T-cell factor (TCF) DNA-binding pr...

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Detalhes bibliográficos
Main Authors: Hecht, Andreas, Kemler, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083688/
https://ncbi.nlm.nih.gov/pubmed/11256619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd012
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