Enfuvirtide Resistance Mutations: Impact on Human Immunodeficiency Virus Envelope Function, Entry Inhibitor Sensitivity, and Virus Neutralization

Enfuvirtide (ENF/T-20/Fuzeon), the first human immunodeficiency virus (HIV) entry inhibitor to be licensed, targets a structural intermediate of the entry process. ENF binds the HR1 domain in gp41 after Env has bound CD4, preventing conformational changes needed for membrane fusion. Mutations in HR1...

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Detalles Bibliográficos
Main Authors: Reeves, Jacqueline D., Lee, Fang-Hua, Miamidian, John L., Jabara, Cassandra B., Juntilla, Marisa M., Doms, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069568/
https://ncbi.nlm.nih.gov/pubmed/15795284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.8.4991-4999.2005
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