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A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

The specificity of small interfering RNA (siRNA)-mediated gene silencing is a critical consideration for the application of RNA interference (RNAi). While the discovery of potential off-target effects by siRNAs is of concern, no systematic analysis has been conducted to explore the specificity of RN...

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Detalles Bibliográficos
Main Authors: Du, Quan, Thonberg, Håkan, Wang, Jue, Wahlestedt, Claes, Liang, Zicai
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069010/
https://ncbi.nlm.nih.gov/pubmed/15781493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki312
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