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A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites
The specificity of small interfering RNA (siRNA)-mediated gene silencing is a critical consideration for the application of RNA interference (RNAi). While the discovery of potential off-target effects by siRNAs is of concern, no systematic analysis has been conducted to explore the specificity of RN...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1069010/ https://ncbi.nlm.nih.gov/pubmed/15781493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki312 |
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