Role of Penicillin-Binding Protein 2 (PBP2) in the Antibiotic Susceptibility and Cell Wall Cross-Linking of Staphylococcus aureus: Evidence for the Cooperative Functioning of PBP2, PBP4, and PBP2A

Ceftizoxime, a beta-lactam antibiotic with high selective affinity for penicillin-binding protein 2 (PBP2) of Staphylococcus aureus, was used to select a spontaneous resistant mutant of S. aureus strain 27s. The stable resistant mutant ZOX3 had an increased ceftizoxime MIC and a decreased affinity o...

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Bibliographische Detailangaben
Hauptverfasser: Łęski, Tomasz A., Tomasz, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Physiology and Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064008/
https://ncbi.nlm.nih.gov/pubmed/15716453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.5.1815-1824.2005
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