Restoration of Susceptibility of Methicillin-resistant Staphylococcus aureus to β-Lactam Antibiotics by Acidic pH: ROLE OF PENICILLIN-BINDING PROTEIN PBP 2a

Methicillin-resistant Staphylococcus aureus (MRSA) is a global scourge, and treatment options are becoming limited. The MRSA phenotype reverts to that of β-lactam-sensitive S. aureus when bacteria are grown at pH 5.0 in broth and, more importantly from a medical perspective (protracted, relapsing in...

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Bibliografiske detaljer
Main Authors: Lemaire, Sandrine, Fuda, Cosimo, Van Bambeke, Françoise, Tulkens, Paul M., Mobashery, Shahriar
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Enzyme Catalysis and Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442357/
https://ncbi.nlm.nih.gov/pubmed/18337244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800079200
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