An Escherichia coli Expression Assay and Screen for Human Immunodeficiency Virus Protease Variants with Decreased Susceptibility to Indinavir

We have developed a recombinant Escherichia coli screening system for the rapid detection and identification of amino acid substitutions in the human immunodeficiency virus (HIV) protease associated with decreased susceptibility to the protease inhibitor indinavir (MK-639; Merck & Co.). The assay de...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Melnick, Laurence, Yang, Shiow-Shong, Rossi, Rick, Zepp, Charlie, Heefner, Donald
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106031/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9835523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.12.3256
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