An Escherichia coli Expression Assay and Screen for Human Immunodeficiency Virus Protease Variants with Decreased Susceptibility to Indinavir

We have developed a recombinant Escherichia coli screening system for the rapid detection and identification of amino acid substitutions in the human immunodeficiency virus (HIV) protease associated with decreased susceptibility to the protease inhibitor indinavir (MK-639; Merck & Co.). The assa...

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Bibliografske podrobnosti
Main Authors: Melnick, Laurence, Yang, Shiow-Shong, Rossi, Rick, Zepp, Charlie, Heefner, Donald
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC106031/
https://ncbi.nlm.nih.gov/pubmed/9835523
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