Inhibition of Human Immunodeficiency Virus Type 1 Infection in SCID-hu Thy/Liv Mice by the G-Quartet-Forming Oligonucleotide, ISIS 5320

Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activity was observed against the T-cell-tropic molecula...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Stoddart, Cheryl A., Rabin, Linda, Hincenbergs, Mara, Moreno, Mary e., Linquist-Stepps, Valerie, Leeds, Janet M., Truong, Lo Anne, Wyatt, J. R., Ecker, David J., McCune, Joseph M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105876/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9687417/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.8.2113
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