Inhibition of Human Immunodeficiency Virus Type 1 Infection in SCID-hu Thy/Liv Mice by the G-Quartet-Forming Oligonucleotide, ISIS 5320

Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activity was observed against the T-cell-tropic molecula...

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Autors principals: Stoddart, Cheryl A., Rabin, Linda, Hincenbergs, Mara, Moreno, Mary e., Linquist-Stepps, Valerie, Leeds, Janet M., Truong, Lo Anne, Wyatt, J. R., Ecker, David J., McCune, Joseph M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC105876/
https://ncbi.nlm.nih.gov/pubmed/9687417
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