Superior Efficacy of Liposomal Amphotericin B with Prolonged Circulation in Blood in the Treatment of Severe Candidiasis in Leukopenic Mice

In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable Candida albicans in...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	van Etten, Els W. M., Snijders, Susan V., van Vianen, Wim, Bakker-Woudenberg, Irma A. J. M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105847/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.9.2431
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