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Superior Efficacy of Liposomal Amphotericin B with Prolonged Circulation in Blood in the Treatment of Severe Candidiasis in Leukopenic Mice

In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable Candida albicans in...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: van Etten, Els W. M., Snijders, Susan V., van Vianen, Wim, Bakker-Woudenberg, Irma A. J. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105847/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736577/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.9.2431
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