A237T as a Modulating Mutation in Naturally Occurring Extended-Spectrum TEM-Type β-Lactamases

A TEM-1 β-lactamase derivative containing the single amino acid substitution A237T slightly increased (from 24 to 32 μg/ml) the cephalothin MIC for Escherichia coli RYC1000 but did not influence the activities of cefotaxime, ceftazidime, and aztreonam (MICs of 0.03, 0.12, and 0.06 μg/ml, respectivel...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Blázquez, Jesús, Negri, María-Cristina, Morosini, María-Isabel, Gómez-Gómez, J. M., Baquero, Fernando
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105741/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9593123/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.5.1042
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