A237T as a Modulating Mutation in Naturally Occurring Extended-Spectrum TEM-Type β-Lactamases

A TEM-1 β-lactamase derivative containing the single amino acid substitution A237T slightly increased (from 24 to 32 μg/ml) the cephalothin MIC for Escherichia coli RYC1000 but did not influence the activities of cefotaxime, ceftazidime, and aztreonam (MICs of 0.03, 0.12, and 0.06 μg/ml, respectivel...

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Autors principals: Blázquez, Jesús, Negri, María-Cristina, Morosini, María-Isabel, Gómez-Gómez, J. M., Baquero, Fernando
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC105741/
https://ncbi.nlm.nih.gov/pubmed/9593123
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