Characterization of a Murine Monoclonal Antibody to Cryptococcus neoformans Polysaccharide That Is a Candidate for Human Therapeutic Studies

The murine monoclonal antibody (MAb) 18B7 [immunoglobulin G1(κ)] is in preclinical development for treatment of Cryptococcus neoformans infections. In anticipation of its use in humans, we defined the serological and biological properties of MAb 18B7 in detail. Structural comparison to the related p...

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Hoofdauteurs: Casadevall, Arturo, Cleare, Wendy, Feldmesser, Marta, Glatman-Freedman, Aharona, Goldman, David L., Kozel, Thomas R., Lendvai, Nikoletta, Mukherjee, Jean, Pirofski, Liise-anne, Rivera, Johanna, Rosas, Angel L., Scharff, Matthew D., Valadon, Philippe, Westin, Katherine, Zhong, Zhaojing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 1998
Onderwerpen:
Biologic Response Modifiers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC105619/
https://ncbi.nlm.nih.gov/pubmed/9624491
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