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Effect of Grapefruit Juice on Clarithromycin Pharmacokinetics

To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of...

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Autors principals: Cheng, Kit L., Nafziger, Anne N., Peloquin, Charles A., Amsden, Guy W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC105569/
https://ncbi.nlm.nih.gov/pubmed/9559810
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