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Effects of Probenecid and Cimetidine on Renal Disposition of Ofloxacin in Rats

The renal handling of ofloxacin in rats which were given ofloxacin either alone or in combination with probenecid or cimetidine was studied. In the presence of cimetidine or probenecid, ofloxacin’s total and renal clearances were reduced and its half-life was prolonged. This suggests that ofloxacin...

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Autors principals: Foote, Edward F., Halstenson, Charles E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC105435/
https://ncbi.nlm.nih.gov/pubmed/9527807
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