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Effects of Probenecid and Cimetidine on Renal Disposition of Ofloxacin in Rats

The renal handling of ofloxacin in rats which were given ofloxacin either alone or in combination with probenecid or cimetidine was studied. In the presence of cimetidine or probenecid, ofloxacin’s total and renal clearances were reduced and its half-life was prolonged. This suggests that ofloxacin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Foote, Edward F., Halstenson, Charles E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 1998
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105435/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9527807/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.2.456
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