Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection

We have recently described GS 4071, a carbocyclic transition-state analog inhibitor of the influenza virus neuraminidase, which has potent inhibitory activity comparable to that of 4-guanidino-Neu5Ac2en (GG167; zanamivir) when tested against influenza A virus replication and neuraminidase activity i...

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Autors principals: Mendel, Dirk B., Tai, Chun Y., Escarpe, Paul A., Li, Weixing, Sidwell, Robert W., Huffman, John H., Sweet, Clive, Jakeman, Kenneth J., Merson, James, Lacy, Steven A., Lew, Willard, Williams, Matthew A., Zhang, Lijun, Chen, Ming S., Bischofberger, Norbert, Kim, Choung U.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC105511/
https://ncbi.nlm.nih.gov/pubmed/9517945
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