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Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection

We have recently described GS 4071, a carbocyclic transition-state analog inhibitor of the influenza virus neuraminidase, which has potent inhibitory activity comparable to that of 4-guanidino-Neu5Ac2en (GG167; zanamivir) when tested against influenza A virus replication and neuraminidase activity i...

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Published in:Antimicrob Agents Chemother
Main Authors: Mendel, Dirk B., Tai, Chun Y., Escarpe, Paul A., Li, Weixing, Sidwell, Robert W., Huffman, John H., Sweet, Clive, Jakeman, Kenneth J., Merson, James, Lacy, Steven A., Lew, Willard, Williams, Matthew A., Zhang, Lijun, Chen, Ming S., Bischofberger, Norbert, Kim, Choung U.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1998
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105511/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9517945/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.3.640
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