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Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection

We have recently described GS 4071, a carbocyclic transition-state analog inhibitor of the influenza virus neuraminidase, which has potent inhibitory activity comparable to that of 4-guanidino-Neu5Ac2en (GG167; zanamivir) when tested against influenza A virus replication and neuraminidase activity i...

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Publicado en:Antimicrob Agents Chemother
Principais autores: Mendel, Dirk B., Tai, Chun Y., Escarpe, Paul A., Li, Weixing, Sidwell, Robert W., Huffman, John H., Sweet, Clive, Jakeman, Kenneth J., Merson, James, Lacy, Steven A., Lew, Willard, Williams, Matthew A., Zhang, Lijun, Chen, Ming S., Bischofberger, Norbert, Kim, Choung U.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1998
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105511/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9517945/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.3.640
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