Kenyan Plasmodium falciparum Field Isolates: Correlation between Pyrimethamine and Chlorcycloguanil Activity In Vitro and Point Mutations in the Dihydrofolate Reductase Domain

Sixty-nine Kenyan Plasmodium falciparum field isolates were tested in vitro against pyrimethamine (PM), chlorcycloguanil (CCG), sulfadoxine (SD), and dapsone (DDS), and their dihydrofolate reductase (DHFR) genotypes were determined. The in vitro data show that CCG is more potent than PM and that DDS...

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Главные авторы: Nzila-Mounda, A., Mberu, E. K., Sibley, C. H., Plowe, C. V., Winstanley, P. A., Watkins, W. M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 1998
Предметы:
Susceptibility
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC105474/
https://ncbi.nlm.nih.gov/pubmed/9449279
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