Kenyan Plasmodium falciparum Field Isolates: Correlation between Pyrimethamine and Chlorcycloguanil Activity In Vitro and Point Mutations in the Dihydrofolate Reductase Domain

Sixty-nine Kenyan Plasmodium falciparum field isolates were tested in vitro against pyrimethamine (PM), chlorcycloguanil (CCG), sulfadoxine (SD), and dapsone (DDS), and their dihydrofolate reductase (DHFR) genotypes were determined. The in vitro data show that CCG is more potent than PM and that DDS...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Nzila-Mounda, A., Mberu, E. K., Sibley, C. H., Plowe, C. V., Winstanley, P. A., Watkins, W. M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 1998
विषय:
Susceptibility
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC105474/
https://ncbi.nlm.nih.gov/pubmed/9449279
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