Comparison of Pharmacodynamics of Azithromycin and Erythromycin In Vitro and In Vivo

In this study, we determined the efficacy of various dosing regimens for erythromycin and azithromycin against four pneumococci with different susceptibilities to penicillin in an in vitro pharmacokinetic model and in a mouse peritonitis model. The MIC was 0.03 μg/ml, and the 50% effective doses (de...

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Bibliographic Details
Main Authors: den Hollander, Jan G., Knudsen, Jenny D., Mouton, Johan W., Fuursted, Kurt, Frimodt-Møller, Niels, Verbrugh, Henri A., Espersen, Frank
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC105417/
https://ncbi.nlm.nih.gov/pubmed/9527789
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