Selection of Resistant Streptococcus pneumoniae during Penicillin Treatment In Vitro and in Three Animal Models

Pharmacokinetic (PK) and pharmacodynamic (PD) properties for the selection of resistant pneumococci were studied by using three strains of the same serotype (6B) for mixed-culture infection in time-kill experiments in vitro and in three different animal models, the mouse peritonitis, the mouse thigh...

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Main Authors: Knudsen, Jenny Dahl, Odenholt, Inga, Erlendsdottir, Helga, Gottfredsson, Magnus, Cars, Otto, Frimodt-Møller, Niels, Espersen, Frank, Kristinsson, Karl G., Gudmundsson, Sigurdur
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166083/
https://ncbi.nlm.nih.gov/pubmed/12878511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.8.2499-2506.2003
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