Identification of RB1 germline mutations in Argentinian families with sporadic bilateral retinoblastoma.

Hereditary predisposition to retinoblastoma is caused by germline mutations in the RB1 gene. Most of these mutations occur de novo and differ from one patient to another. DNA samples from 10 families with a child presenting sporadic bilateral retinoblastoma have been analysed for the causative mutat...

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Bibliographic Details
Main Authors: Szijan, I, Lohmann, D R, Parma, D L, Brandt, B, Horsthemke, B
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1050489/
https://ncbi.nlm.nih.gov/pubmed/7666401
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