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Constitutional RB1-gene mutations in patients with isolated unilateral retinoblastoma.

In most patients with isolated unilateral retinoblastoma, tumor development is initiated by somatic inactivation of both alleles of the RB1 gene. However, some of these patients can transmit retinoblastoma predisposition to their offspring. To determine the frequency and nature of constitutional RB1...

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Bibliografische gegevens
Hoofdauteurs: Lohmann, D R, Gerick, M, Brandt, B, Oelschläger, U, Lorenz, B, Passarge, E, Horsthemke, B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1997
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1715910/
https://ncbi.nlm.nih.gov/pubmed/9311732
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