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Adenovirus Type 5 E4orf3 Protein Relieves p53 Inhibition by E1B-55-Kilodalton Protein
The E1B-55-kDa protein of adenovirus type 5 and the p53 tumor suppressor gene product form a complex that localizes to the cytoplasm, thereby downregulating p53’s transcriptional activity. The E4orf6 protein binds and relocalizes E1B-55-kDa, and the proteins act synergistically to inactivate p53. We...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
1999
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC104470/ https://ncbi.nlm.nih.gov/pubmed/9971808 |
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