Adenovirus Type 5 E4orf3 Protein Relieves p53 Inhibition by E1B-55-Kilodalton Protein

The E1B-55-kDa protein of adenovirus type 5 and the p53 tumor suppressor gene product form a complex that localizes to the cytoplasm, thereby downregulating p53’s transcriptional activity. The E4orf6 protein binds and relocalizes E1B-55-kDa, and the proteins act synergistically to inactivate p53. We...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	König, Claudia, Roth, Judith, Dobbelstein, Matthias
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Materias:	Transformation and Oncogenesis
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104470/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9971808/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.3.2253-2262.1999
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