B-myb Promoter Retargeting of Herpes Simplex Virus γ34.5 Gene-Mediated Virulence toward Tumor and Cycling Cells

Deletion of the γ34.5 gene coding for virulence markedly reduces cytotoxicity mediated by herpes simplex virus type 1 (HSV-1) (J. M. Markert et al., Neurosurgery 32:597–603, 1993; N. S. Markovitz et al., J. Virol. 71:5560–5569, 1997). To target lytic virulence to tumors, we have created a novel HSV-...

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Main Authors: Chung, Richard Y., Saeki, Yoshinaga, Chiocca, E. Antonio
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 1999
主題:
Gene Therapy
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC104282/
https://ncbi.nlm.nih.gov/pubmed/10438845
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